What are PPIs?
It may be natural to confuse PPIs with those hidden fees that banks charged you for years without disclosing those fees to you. But the acronym “PPIs” stands for proton-pump inhibitors, a class of drugs that cause a profound and prolonged reduction of stomach acid production. They do so by inhibiting the stomach's gastric hydrogen-potassium ATPase proton pump, a process that is reversible upon discontinuity.
The role of PPIs in chronic disorders
Inhibiting the hydrogen-potassium pump (H+/K+-ATPase) to decrease stomach acid production has been the most common method of treating gastroesophageal reflux disease (GERD/GORD) and peptic ulcer disease. While this may be a quick fix, it doesn’t address the actual cause.
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